解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Hexokinase-II (HK2) is a key enzyme involved in glycolysis, which is required for breast cancer progression. However, the underlying post-translational mechanisms of HK2 activity are poorly understood. Here, we showed that Proviral Insertion in Murine Lymphomas 2 (PIM2) directly bound to HK2 and phosphorylated HK2 on ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-018-0386-x
更新日期:2018-11-01 00:00:00
abstract::Aberrant activation of anaplastic lymphoma kinase (ALK) can cause sporadic and familial neuroblastoma. Using a proteomics approach, we identified Bruton's tyrosine kinase (BTK) as a novel ALK interaction partner, and the physical interaction was confirmed by co-immunoprecipitation. BTK is expressed in neuroblastoma ce...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-018-0397-7
更新日期:2018-11-01 00:00:00
abstract::Osteoclasts are multinuclear bone-resorbing cells that differentiate from hematopoietic precursor cells. Prostate cancer cells frequently spread to bone and secrete soluble signaling factors to accelerate osteoclast differentiation and bone resorption. However, processes and mechanisms that govern the expression of os...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-018-0356-3
更新日期:2018-10-01 00:00:00
abstract::Understanding the molecular mechanisms that underlie the aggressive behavior and relapse of breast cancer may help in the development of novel therapeutic interventions. CUB-domain-containing protein 1 (CDCP1), a transmembrane adaptor protein, is highly maintained and required in the context of cellular metastatic pot...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-018-0372-3
更新日期:2018-10-01 00:00:00
abstract::Pleckstrin homology domain leucine-rich repeat protein phosphatase 2 (PHLPP2) is a tumor suppressor that catalyzes the de-phosphorylation of the AGC kinases, while p27 acts as a tumor suppressor that regulates cell cycle, apoptosis, and cell motility. Our previous studies have identified that PHLPP2 participates in in...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-018-0374-1
更新日期:2018-10-01 00:00:00
abstract::Metabolic acid production challenges cellular pH homeostasis in solid cancer tissue, and mechanisms of net acid extrusion represent promising new targets for breast cancer therapy. Here, we used genetically engineered mice to investigate the contribution of the Na+,HCO3--cotransporter NBCn1 (Slc4a7) to intracellular a...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-018-0353-6
更新日期:2018-10-01 00:00:00
abstract::Liver metastasis remains a serious problem in the management of gastric cancer (GC). Our aims were to identify through transcriptome analysis a molecule that mediates hepatic metastasis in GC, and to evaluate its potential as a diagnostic marker and a therapeutic target. The effects of knocking out a relevant molecule...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-018-0335-8
更新日期:2018-09-01 00:00:00
abstract::The chromatin state is finely tuned to regulate function and specificity for transcription factors such as oestrogen receptor alpha (ER), which contributes to cell growth in breast cancer. ER transcriptional potential is mediated, in large part, by the specific associated proteins and co-factors that interact with it....
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-018-0312-2
更新日期:2018-09-01 00:00:00
abstract::Epithelial-mesenchymal transition (EMT) facilitates cancer invasion and metastasis and thus accelerates cancer progression. p21-activated kinase 4 (PAK4) is a critical regulator of prostate cancer (PC) progression. Here, we report that PAK4 activation promotes PC progression through the EMT regulator Slug. We find tha...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-018-0327-8
更新日期:2018-09-01 00:00:00
abstract::Fas-associated death domain (FADD) is an adaptor protein recruiting complexes of caspase 8 to death ligand receptors to induce extrinsic apoptotic cell death in response to a TNF superfamily member. Although, formation of the complex of FADD and caspase 8 upon death stimuli has been studied in detail, posttranslationa...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-018-0323-z
更新日期:2018-09-01 00:00:00
abstract::Non-small cell lung cancer (NSCLC) is the most common type of lung cancer, and multiple evidence has confirmed that C5a production is elevated in NSCLC microenvironment. Although NSCLC cell proliferation induced by C5a has been reported, the involved mechanism has not been elucidated. In this study, we examined the pr...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-018-0298-9
更新日期:2018-08-01 00:00:00
abstract::While advances in laboratory automation has dramatically increased throughout of compound screening efforts, development of robust cell-based assays in relevant disease models remain resource-intensive and time-consuming, presenting a bottleneck to drug discovery campaigns. To address this issue, we present a modified...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-018-0274-4
更新日期:2018-08-01 00:00:00
abstract::Primary cilia are microtubule-based, dynamic organelles characterized by continuous assembly and disassembly. The intraflagellar transport (IFT) machinery, including IFT88 in cilia, is involved in the maintenance of bidirectional motility along the axonemes, which is required for ciliogenesis and functional competence...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-018-0211-6
更新日期:2018-08-01 00:00:00
abstract::Intrinsic and acquired resistance to anti-EGFR antibody therapy, frequently mediated by a mutant or amplified KRAS oncogene, is a significant challenge in the treatment of colorectal cancer (CRC). However, the mechanism of KRAS-mediated therapeutic resistance is not well understood. In this study, we demonstrate that ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-018-0289-x
更新日期:2018-08-01 00:00:00
abstract::Pancreatic ductal adenocarcinoma (PDAC) is a deadly disease and a major health problem in the United States. While the cytokine TGF-β has been implicated in PDAC development, it can exert both pro-tumorigenic and anti-tumorigenic effects that are highly context dependent and incompletely understood. Using three-dimens...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-018-0264-6
更新日期:2018-08-01 00:00:00
abstract::Antineoplastic platinum agents are used in first-line treatment of ovarian cancer, but treatment failure frequently results from platinum drug resistance. Emerging observations suggest a role of reactive oxygen species (ROS) in the resistance of cancer drugs including platinum drugs. However, the molecular link betwee...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-018-0238-8
更新日期:2018-07-01 00:00:00
abstract::Oncogene-induced senescence (OIS) is an intrinsic tumor suppression mechanism that requires the p53 and RB pathways and post-translational activation of C/EBPβ through the RAS-ERK cascade. We previously reported that in transformed/proliferating cells, C/EBPβ activation is inhibited by G/U-rich elements (GREs) in its ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-018-0190-7
更新日期:2018-06-01 00:00:00
abstract::The RAS-RAF-MEK-ERK signaling cascade is among the most frequently mutated pathways in human cancer. Approximately 50% of melanoma patients possess a druggable hotspot V600E/K mutation in the BRAF protein kinase. FDA-approved combination therapies of BRAF and MEK inhibitors are available that provide survival benefits...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/s41388-018-0171-x
更新日期:2018-06-01 00:00:00
abstract::Nuclear activated β-catenin plays a causative role in colorectal cancers (CRC) but remains an elusive therapeutic target. Using human CRC cells harboring different Wnt/β-catenin pathway mutations in APC/KRAS or β-catenin/KRAS genes, and both genetic and pharmacological knockdown approaches, we show that oncogenic β-ca...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-018-0170-y
更新日期:2018-06-01 00:00:00
abstract::Liver tumor-initiating cells (TICs), the drivers for liver tumorigenesis, accounts for liver tumor initiation, metastasis, drug resistance and relapse. Wnt/β-catenin signaling pathway emerges as a critical modulator in liver TIC self-renewal. However, the molecular mechanism of Wnt/β-catenin initiation in liver tumori...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-018-0203-6
更新日期:2018-06-01 00:00:00
abstract::The study and comprehension of the molecular mechanisms underlying cancer biology strongly rely on mouse modeling. An ideal mouse model should have molecular, histopathological, and etiological characteristics as close as possible to those of the corresponding human tumors. Among solid tumors, colorectal cancer (CRC) ...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/s41388-018-0155-x
更新日期:2018-05-01 00:00:00
abstract::Chronic exposure to intraperitoneal asbestos triggered a marked response in the mesothelium well before tumor development. Macrophages, mesothelial precursor cells, cytokines, and growth factors accumulated in the peritoneal lavage. Transcriptome profiling revealed YAP/TAZ activation in inflamed mesothelium with furth...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-018-0153-z
更新日期:2018-05-01 00:00:00
abstract::Signal transducer and activator of transcription 3 (STAT3) is constitutively activated in malignant tumors and plays important roles in multiple aspects of cancer aggressiveness. Thus, targeting STAT3 promises to be an attractive strategy for the treatment of advanced metastatic tumors. Bisindolylmaleimide alkaloid (B...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-017-0076-0
更新日期:2018-05-01 00:00:00
abstract::The T-box transcription factor TBX3 has been implicated in the patterning and differentiation of a number of tissues during embryonic development, and is overexpressed in a variety of cancers; however, the precise function of TBX3 in papillary thyroid carcinoma (PTC) development remains to be determined. In the curren...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-017-0090-2
更新日期:2018-05-01 00:00:00
abstract::A better understanding of the link between cellular metabolism and tumorigenesis is needed. Here, we report characterization of a novel protein named coiled-coil helix tumor and metabolism 1 (CHTM1). We have found that CHTM1 is associated with cancer and cellular metabolism. CHTM1 localizes to mitochondria and cytosol...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-017-0051-9
更新日期:2018-04-01 00:00:00
abstract::Basal type breast cancer is the most aggressive and has mesenchymal features with a high metastatic ability. However, the signaling node that determines the basal type features in breast cancer remains obscure. Here, we report that FYN among SRC family kinases is required for the maintenance of basal type breast cance...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-017-0114-y
更新日期:2018-04-01 00:00:00
abstract::Hedgehog (Hh) is an oncogenic signaling pathway that regulates the activity of Gli transcription factors. Canonical Hh is a Smoothened- (Smo-) driven process that alters the post-translational processing of Gli2/Gli3 proteins. Though evidence supports a role for Gli action in prostate cancer (PCa) cell growth and prog...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-017-0098-7
更新日期:2018-04-01 00:00:00
abstract::Ovarian cancer (OvCa) is characterized by widespread and rapid metastasis in the peritoneal cavity. Visceral adipocytes promote this process by providing fatty acids (FAs) for tumour growth. However, the exact mechanism of FA transfer from adipocytes to cancer cells remains unknown. This study shows that OvCa cells co...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-017-0093-z
更新日期:2018-04-01 00:00:00
abstract::PI3K/AKT pathway activation is thought to be a driving force in metastatic melanomas. Members of the pleckstrin homology (PH) domain leucine-rich repeat protein Ser/Thr specific phosphatase family (PHLPP1 and PHLPP2) can regulate AKT activation. By dephosphorylating specific serine residues in the hydrophobic motif, P...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-017-0061-7
更新日期:2018-04-01 00:00:00
abstract::Tumor stroma has an active role in the initiation, growth, and propagation of many tumor types by secreting growth factors and modulating redox status of the microenvironment. Although PPARβ/δ in fibroblasts was shown to modulate oxidative stress in the wound microenvironment, there has been no evidence of a similar e...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-017-0109-8
更新日期:2018-04-01 00:00:00
abstract::Migration and invasion inhibitory protein (MIIP) is recently identified as an inhibitor in tumor development. However, the regulatory mechanism and biological contributions of MIIP in pancreatic cancer (PC) have been not elucidated. In this study, we demonstrated a negative feedback of MIIP and hypoxia-induced factor-...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-017-0082-2
更新日期:2018-03-01 00:00:00
abstract::Persistent infection by high-risk human papillomaviruses (HPVs) is associated with the development of cervical cancer and a subset of anogenital and head and neck squamous cell carcinomas. Abnormal expression of cellular microRNAs (miRNAs) plays an important role in the development of cancer, including HPV-related tum...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-017-0083-1
更新日期:2018-03-01 00:00:00
abstract::BRAF mutations occur in ~10% of colorectal cancer (CRC) and are associated with poor prognosis. Inhibitors selective for the BRAFV600E oncoprotein, the most common BRAF mutant, elicit only poor response rates in BRAF-mutant CRC as single agents. This unresponsiveness was mechanistically attributed to the loss of negat...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-017-0063-5
更新日期:2018-03-01 00:00:00
abstract::Protein kinase D2 (PKD2) is a serine/threonine kinase that belongs to the PKD family of calcium-calmodulin kinases, which comprises three isoforms: PKD1, PKD2, and PKD3. PKD2 is activated by many stimuli including growth factors, phorbol esters, and G-protein-coupled receptor agonists. PKD2 participation to uncontroll...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/s41388-017-0052-8
更新日期:2018-03-01 00:00:00
abstract::The proangiogenic cytokine Interleukin-3 (IL-3) is released by inflammatory cells in breast and ovarian cancer tissue microenvironments and also acts as an autocrine factor for human breast and kidney tumor-derived endothelial cells (TECs). We have previously shown that IL-3-treated endothelial cells (ECs) release ext...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-017-0034-x
更新日期:2018-03-01 00:00:00
abstract::Constitutively active AR-V7, one of the major androgen receptor (AR) splice variants lacking the ligand-binding domain, plays a key role in the development of castration-resistant prostate cancer (CRPC) and anti-androgen resistance. However, our understanding of the regulatory mechanisms of AR-V7-driven transcription ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-017-0047-5
更新日期:2018-03-01 00:00:00
abstract::Activating mutations of the ALK receptor occur in a subset of neuroblastoma tumors. We previously demonstrated that Alk mutations cooperate with MYCN overexpression to induce neuroblastoma in mice and identified Ret as being strongly upregulated in MYCN/Alkmut tumors. By a genetic approach in vivo, we now document an ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-017-0039-5
更新日期:2018-03-01 00:00:00
abstract::Glycolysis is critical for cancer stem cell reprogramming; however, the underlying regulatory mechanisms remain elusive. Here, we show that pyruvate dehydrogenase kinase 1 (PDK1) is enriched in breast cancer stem cells (BCSCs), whereas depletion of PDK1 remarkably diminishes ALDH+ subpopulations, decreases stemness-re...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2017.368
更新日期:2018-02-22 00:00:00
abstract::During normal tumor growth and in response to some therapies, tumor cells experience acute or chronic deprivation of nutrients and oxygen and induce tumor vascularization. While this occurs predominately through sprouting angiogenesis, tumor cells have also been shown to directly contribute to vessel formation through...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2017.356
更新日期:2018-02-22 00:00:00
abstract::Various factors and cellular components in the tumor microenvironment are key drivers associated with drug resistance in many cancers. Here, we analyzed the factors and molecular mechanisms involved in chemoresistance in patients with esophageal squamous cell carcinoma (ESCC). We found that interleukin 6 (IL6) derived...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2017.387
更新日期:2018-02-15 00:00:00